Risk Assessment and Toxicology Steering Committee Publications

The following reports, prepared by the Risk Assessment and Toxicology Steering Committee (RATSC) in 1999, are available as pdf files.

 

From Risk Assessment to Risk Management: Dealing with Uncertainty

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This document is a report arising from a workshop held in 1999 to examine the various influences on approaches for dealing with uncertainty in the toxicological component of chemical risk assessment. Five case studies were used to examine current practice, and a number of recommendations are discussed.

Exposure Assessment in the Evaluation of Risk to Human Health

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This document is a report arising from a workshop held in 1998 to explore issues associated with exposure assessment in the evaluation of risk to human health. Background papers were presented on exposure assessment of chemicals in food and consumer products, water, soil and air, and the occupational environment. A number of recommendations arising out of the workshop are discussed.

Physiologically-Based Pharmacokinetic Modelling: A Potential Tool for Use in Risk Assessment

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This document is a report arising from a workshop held in 1997 to examine PBPK modelling in chemical risk assessment, particularly within the regulatory context. Recommendations are made for areas of future research activity.

Risk Assessment Strategies in Relation to Population Subgroups

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This document is a report arising from a workshop held in 1997 to examine the scientific basis of extrapolation procedures and suggest how these procedures could be improved and to consider whether special risk assessment provision should be made for certain population subgroups. The report recommends research to help resolve outstanding problems.

Risk Assessment Approaches used by UK Government for Evaluating Human Health Effects of Chemicals

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This report is a full review of approaches to chemical risk assessments carried out by UK Government departments and agencies, as outlined in cr1. The report includes detailed recommendations on harmonisation, and the development of improved methods and transparency in risk assessments.

Developing New Approaches to Assessing Risk to Human Health from Chemicals

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This report outlines the background to a review of current risk assessment processes and identifies diversities in approach in three key areas carried out by government departments and agencies (uncertainties, variability, hazard identification data). As a result of this review, four workshops were held in 1997, and the report discusses key recommendations arising out of these workshops.